Fundamental research

How does a cell sustain a lipid signal under constant drain? Mathematical models of the PI(4,5)P₂ cycle in fly photoreceptors, feedback optimisation, and the regulatory networks of zebrafish heart development — with time at the bench.

Period: 2012 — 2021
Where: NCBS-TIFR · IIMCB Warsaw
Role: PhD · Postdoc

Selected work

2020Regulatory networks of zebrafish heart developmentPostdoc · IIMCB Warsaw (Winata Lab)
2018Sinks and sources in the PIP₂ cycleFEBS Letters · first authorRead paper ↗
2018Structure and dynamics of the Drosophila PI(4,5)P₂ cyclePhD · NCBS-TIFRRead thesis ↗

All 3 projects in fundamental research →

The research years

2012PhD · NCBS-TIFRModelling the PI(4,5)P₂ cycle in fly photoreceptors
2015Talk · RIKEN, JapanNCBS–RIKEN joint meeting
2017Talk · DenmarkPhysical Concepts in Stem Cell Biology
2018PhD · FEBS LettersBest poster at NCBS · Young FishMed speaker
2019Postdoc · IIMCB WarsawRegulatory networks of zebrafish heart development
2021Into industryModels meet clinical data at nference

Methods

ODE & Boolean models
Parameter & feedback optimisation
Network inference
sympy · Z3

At the bench

Protein purification
Fly genetics
Electroretinography
Cloning · imaging

Approach

Monte Carlo simulation
Graph theory
Systems biology
Model-driven experiments

Trajectories spiralling into a steady state